Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.

نویسندگان

  • Ingo Ott
  • Konrad Kowalski
  • Ronald Gust
  • Jörg Maurer
  • Philipp Mücke
  • Rainer F Winter
چکیده

Two ethylene linked binuclear mixed ferrocene/ruthenium complexes were biologically investigated in comparison to structurally related mononuclear ferrocene or ruthenium species with styryl substituents or ligands. Results indicated that the electron distribution (but not the redox potential), cellular uptake and (to some minor extent) anti-estrogenic effects were the key contributors to antiproliferative effects observed in tumor cell lines.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 20 3  شماره 

صفحات  -

تاریخ انتشار 2010